James Brown

James Brown

Senior Lecturer, Imaging/Vision

Selected Publications

Automated Diagnosis of Plus Disease in Retinopathy of Prematurity Using Deep Convolutional Neural Networks

Published in JAMA Ophthalmology, 2018

This fully automated algorithm diagnosed plus disease in ROP with comparable or better accuracy than human experts. This has potential applications in disease detection, monitoring, and prognosis in infants at risk of ROP.

Recommended citation: Brown, et al. (2018). "Automated Diagnosis of Plus Disease in Retinopathy of Prematurity Using Deep Convolutional Neural Networks" JAMA Ophthalmology. 136(7). https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2680579

Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models

Published in Medical Image Analysis, 2017

This paper presents a fully automated method for obtaining quantitative measurements of bone destruction from volumetric micro-CT images of a mouse hind paw.

Recommended citation: Brown, et al. (2017). "Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models" Medical Image Analysis. 40. https://www.sciencedirect.com/science/article/pii/S1361841517300774

High-throughput discovery of novel developmental phenotypes

Published in Nature, 2016

Using a standardized phenotyping platform that incorporates high-resolution 3D imaging, we identify phenotypes at multiple time points for previously uncharacterized genes and additional phenotypes for genes with previously reported mutant phenotypes.

Recommended citation: Dickinson, et al. (2016). "High-throughput discovery of novel developmental phenotypes." Nature. 537(7621). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821/